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3 raisons identifiées
Auteur de référence en rhumatologie
37 articles scientifiques publiés — un praticien à la pointe de la recherche
Disponibilité géographique
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121.5 rhumatos / 100 000 hab. — département bien doté
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CLINIQUE CHIRURGICALE DE LA LOIRE
R DES ROLLETIERES BP 50040, 49402 SAUMUR CEDEX
CABINET DU DR MARIA-TERESA FARRES-GIBERT
GIE CENTRE HOSPITALIER DE SAUMUR ROUTE DE FONTEVRAUD, 49403 SAUMUR CEDEX
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Stem cells translational medicine · 2021
Abstract Buerger's disease or thromboangiitis obliterans is a type of obstructive vascular diseases categorized as vasculitis and usually present in 95% of young smoker men. The main pathogenetic mechanism is interplay between immune system and inflammation. Earlier our phase II study has shown that Stempeucel is safe when injected at 2 million cells/kg body weight by virtue of its anti-inflammatory, immunomodulatory, and angiogenetic properties. The present study was conducted to further assess the safety and efficacy of Stempeucel in critical limb ischemia due to Buerger's disease after obtaining approval from Indian FDA based on the data generated in the phase II study. This is an open label, multicenteric phase IV PMS study conducted across India with experienced vascular surgeons. Fifty patients of critical limb ischemia due to Buerger's disease with Rutherford III-5 or III-6 were included in the study and each individual received a dose of 2 million cells/kg body weight of Stempeucel in the calf muscles and around the ulcer. These patients were evaluated over 12 months from drug administration. The present study showed the continued long term efficacy over a period of 12 months follow up in these patients corroborating the result obtained in the previous phase II studies. There was significant improvement in rest pain, ankle systolic pressure, and ankle brachial pressure index with accelerated ulcer healing. In conclusion, the present study shows that the intramuscular administration of Stempeucel continues to be safe, tolerable, and effective alternative treatment in patients with Buerger's disease.
The Journal of the Association of Physicians of India · 2022
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
The Journal of international medical research · 2026 · Journal Article
Been Sayeed SKJ, M M, Mahmud R, Rahman S, et al.
Bioinformation · 2025 · Journal Article
G N, M SSL, V S, K S, et al.
Brain, behavior, & immunity - health · 2023 · Journal Article
Graïc JM, Finos L, Vadori V, Cozzi B, et al.
PLoS neglected tropical diseases · 2023 · Journal Article
Guttapadu R, Prakash N, M A, Chatterjee R, et al.
medRxiv : the preprint server for health sciences · 2022 · Preprint
Ghosh P, Niesen MJM, Pawlowski C, Bandi H, et al.
Osteoarthritis and cartilage open · 2021 · Journal Article
A D, A T, T J, O R, et al.
Current computer-aided drug design · 2020 · Journal Article
M S, B P, Swaminathan P
Infection & chemotherapy · 2019 · Journal Article
Raffaella G, Lorenzo L, Elisabetta X, Andrea A, et al.
Drug design, development and therapy · 2019 · Journal Article
Kameoka Y, F K, M K
International journal of biological macromolecules · 2018 · Journal Article
S S, R S, V U, B A, et al.
BMC genomics · 2016 · Journal Article
Shay JW, Homma N, Zhou R, Naseer MI, et al.
Journal of orthopaedic case reports · 2014 · Case Reports
M DM, R BS, M WR
The open orthopaedics journal · 2012 · Journal Article
M M, H G, S H, A J, et al.
International journal of vascular medicine · 2011 · Case Reports
Giovanni N, Daniela M, Giovanni M, Maria Teresa O, et al.
Physiotherapy · 2026 · Letter
Rashid FA, M RP
Animals : an open access journal from MDPI · 2026 · Journal Article
Benjamin ET, Maria Teresa SE, Alexander NS, Stephanie SA, et al.
Journal of orthopaedic case reports · 2018 · Case Reports
Shankar K, M S, Raizada P, Jain R
Clinical rheumatology · 2025 · Journal Article
A K, M EA, M H, H A, et al.
Rheumatology and immunology research · 2024 · Journal Article
Datta D, Khatun M, Bankura B, Sarkar M, et al.
Clinical rheumatology · 2025 · Journal Article
Mohan A, Mohan A, Ramachandran A, Pulinilkunnathil JG, et al.
AACE clinical case reports · 2021 · Case Reports
César Ernesto LC, Álvaro EO, Yayoi SK, Juanita SS, et al.
JACC. Case reports · 2024 · Case Reports
Kharge JL, M UK, M L J, Newaskar AA, et al.
Stem cells translational medicine · 2021 · Clinical Trial, Phase IV
Gupta PK, Dutta S, Kala S, Nekkanti M, et al.
Cureus · 2024 · Case Reports
Surapaneni D, Dasi SC, Sam N, M J
Journal of neurosciences in rural practice · 2020 · Journal Article
Vijayan BV, Nair VCP, M G
JMIR research protocols · 2025 · Journal Article
M A, Ahmad A, A A, Raj LS, et al.
The Journal of the Association of Physicians of India · 2022 · Journal Article
Murugesan H, Cs G, Nasreen HS, Santhanam S, et al.
BMJ case reports · 2025 · Journal Article
Pathrot D, Nachappa AA, Mannual S, M SK
Indian journal of dermatology, venereology and leprology · 2023 · Letter
Rao AG, M N, Ch S, Jhawar J
Radiology case reports · 2023 · Case Reports
Lee ZR, Lai YK, M L, Khor LY, et al.
Journal of orthopaedic case reports · 2018 · Case Reports
Shankar K, M S, Raizada P, Jain R
Cureus · 2025 · Journal Article
Nallaperumal S, V P, M C V, Pusapati LCV, et al.
Archives of gerontology and geriatrics · 2021 · Journal Article
M R, M A, H B, M O
The Egyptian journal of immunology · 2018 · Journal Article
Amin MM, Ibrahim AM, Fahmy EM, Yassin AS, et al.
Cureus · 2022 · Case Reports
Chandra MS, G A M, M RK
Surgery journal (New York, N.Y.) · 2019 · Journal Article
Chan CM, Cisneros EF, M T
Cureus · 2024 · Case Reports
Mohan A, Kuriakose SM, James L, G BT, et al.
Cureus · 2023 · Journal Article
M D, Kumar J, Ramalingam K