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3 raisons identifiées
Auteur de référence en rhumatologie
25 articles scientifiques publiés — un praticien à la pointe de la recherche
Disponibilité géographique
3 lieux d'exercice — choisissez celui qui vous arrange
Délais de RDV courts dans la région
78.3 rhumatos / 100 000 hab. — département bien doté
✨ Génération du profil synthétique IA en cours…
CDS MEDICAL ET DENTAIRE GAGNY
23 AV HENRI BARBUSSE, 93220 GAGNY
CDS MEDICAL DE NEUILLY SUR MARNE
1 PL DES VICTOIRES, 93330 NEUILLY SUR MARNE
Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.
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Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
European heart journal · 2026
Abstract Background and Aims Despite current antithrombotic treatments, the recurrence of ischaemic events remains high in patients with diabetes mellitus (DM) or aspirin resistance after acute coronary syndrome (ACS). Whether twice-daily aspirin dosing reduces major adverse cardiovascular events (MACE) in this population remains unknown. Methods In this prospective multicentre, randomized trial, patients with ACS and DM or high-risk of aspirin resistance (HRAR) defined as: (i) an index event occurring while on aspirin; (ii) body mass index ≥27 kg/m2; or (iii) increased waist circumference were assigned to receive enteric-coated aspirin once daily (100 mg/day) or twice daily (100 mg morning and evening). The primary outcome was MACE, a composite of any death, myocardial infarction, stroke, urgent coronary revascularization, stent thrombosis, or acute arterial thrombotic event assessed using a time-to-first-event analysis. The main secondary outcome was major bleeding (Bleeding Academic Research Consortium type 3–5). Results In total, 2484 participants were enrolled (77.2% with DM, 55.5% with ST-elevation segment myocardial infarction). The median follow-up duration was 18 (interquartile range: 17.6–18.3) months. The primary outcome occurred in 95 of 1228 participants (7.7%) in the twice-daily aspirin group, and 110 of 1256 (8.8%) in the once-daily group (hazard ratio [HR] 0.90; 95% confidence interval [CI] 0.69–1.19; P = .42). Major bleeding rates were similar between the groups (1.9% vs 2.1%; HR 0.88; 95% CI 0.50–1.55). Conclusions In patients with ACS and DM or HRAR, twice-daily aspirin did not significantly reduce the risk of MACE compared to once-daily dosing. No significant difference was observed in major bleeding between groups. Trial Registration NCT02520921/EUDRACT No: 2015-000947-18.
Journal of sleep research · 2026
ABSTRACT Narcolepsy type 1 is a chronic sleep disorder of putative autoimmune aetiology, primarily caused by the loss of orexin‐producing neurons in the hypothalamus. An additional 88% reduction in corticotropin‐releasing hormone‐immunoreactive neurons of the paraventricular nucleus has been recently observed in post‐mortem brains of individuals with narcolepsy type 1. It is, however, unknown whether this reduction is specific to the paraventricular nucleus or involves other brain regions expressing corticotropin‐releasing hormone, such as the amygdala, which plays a central role in mood regulation, stress response and cataplexy. This study examined whether orexin neuron loss and/or hypothalamic neuroinflammation would affect the expression of corticotropin‐releasing hormone and other neuropeptides, including melanin‐concentrating hormone and histidine decarboxylase as a proof of concept. We used quantitative polymerase chain reaction to measure messenger RNA levels in three mice models of narcolepsy type 1: mice lacking orexin due to genetic disruption, mice with toxin‐induced orexin neuron ablation and mice with autoimmune‐mediated orexin neuron loss accompanied by hypothalamic neuroinflammation. We found no change in corticotropin‐releasing hormone expression in both the hypothalamus and amygdala across all models, regardless of the timeline or mechanism of orexin loss. Similarly, the expression of melanin‐concentrating hormone and histidine decarboxylase was unaffected. These findings suggest that the absence of orexin signalling alone is not sufficient to alter corticotropin‐releasing hormone expression. Alternative mechanisms may account for the observation made in human narcolepsy type 1 post‐mortem samples. Future human studies are warranted to identify the underlying processes and determine whether similar changes occur in other brain regions.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Joint bone spine · 2026 · Journal Article
Georges M, Jean-Marc B, Yves-Marie P
Archives of cardiovascular diseases · 2026 · Letter
Cohen A, Lang S, Soulat-Dufour L, Brito E, et al.
Journal of cellular and molecular medicine · 2026 · Journal Article
G P, Shivhare K, Gupta PK, Sahebkar A, et al.
International urology and nephrology · 2026 · Journal Article
Georges K, Aura N, Julien B, Clemence D, et al.
Clinical lymphoma, myeloma & leukemia · 2026 · Journal Article
Al Hadidi S, Costello C, Costa LJ, Dhakal B, et al.
Annals of internal medicine · 2026 · Journal Article
Jay J, Pino E, Georges M, Courtepatte A, et al.
Bulletin du cancer · 2026 · Journal Article
Fleta L, Laffitte PV, Slama B, Trinh I, et al.
EJHaem · 2026 · Journal Article
Marsolais S, Pastore Y, Robitaille N, Desjardins L, et al.
European heart journal · 2026 · Journal Article
Dillinger JG, Pezel T, Batias L, Angoulvant D, et al.
Gut · 2026 · Journal Article
Cao M, Wei F, Georges D, Alberts CJ, et al.
The journal of prevention of Alzheimer's disease · 2026 · Journal Article
Duffner LA, Moradi-Bachiller S, Gove D, Diaz-Ponce AM, et al.
International journal of cancer · 2026 · Journal Article
Hirabayashi M, Georges D, Combes JD, Clifford GM
Physical review. E · 2026 · Journal Article
Moss MS, Orfi A, Roth C, Sengupta AM, et al.
Gut · 2026 · Journal Article
Cao M, Wei F, Georges D, Alberts CJ, et al.
International journal of cancer · 2026 · Journal Article
Hirabayashi M, Georges D, Combes JD, Clifford GM
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026 · Journal Article
Perez Rodriguez Garcia G, Kelbert J, Saleh D, Pico A, et al.
Ophthalmology · 2026 · Journal Article
Germanese C, Georges M, Bonniaud P, Goueslard K, et al.
Journal of sleep research · 2026 · Journal Article
Chorvoz J, Rabec C, Labruyère M, Devilliers H, et al.
Journal of sleep research · 2026 · Journal Article
Zhou J, Melzi S, Morel AL, Georges B, et al.
JAMA cardiology · 2026 · Journal Article
Puymirat E, Soulat G, Lattuca B, Bouleti C, et al.
Nature communications · 2026 · Journal Article
Abdallah M, Nakken S, Georges M, Bierkens M, et al.
Journal of sleep research · 2026 · Journal Article
Zhou J, Melzi S, Morel AL, Georges B, et al.
medRxiv : the preprint server for health sciences · 2026 · Journal Article
Berrandou TE, Georges A, Tarr I, Giannoulatou E, et al.
Annals of neurology · 2026 · Journal Article
B Szabo A, Curot J, Gérard F, Rulquin F, et al.
Nature communications · 2026 · Journal Article
Abdallah M, Nakken S, Georges M, Bierkens M, et al.
BMC geriatrics · 2026 · Journal Article
Georges D, Rakuša E, Becher H, Brandes B, et al.
Clinical science (London, England : 1979) · 2026 · Journal Article
Liu Y, Liu L, Esmael A, Tezza A, et al.
Journal of Alzheimer's disease : JAD · 2026 · Journal Article
Keret O, Xia T, Wilkins S, Ncube LNL, et al.
BMC veterinary research · 2026 · Published Erratum
Eichert C, Theissinger K, Quintard B, Georges JY