M Mohammed FAHIM

Rhumatologue

📍 COMBS LA VILLE (77)LibéralRPPS 10001510683

📊 Reconnaissance scientifique : 12/100📝 51 articles publiés

✨ Génération du profil synthétique IA en cours…

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Indicateurs publics agrégés sur 250 M+ d'œuvres scientifiques (OpenAlex, PubMed). Traduits ici en langage patient.

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12 articles ont été cités au moins 12fois par d'autres chercheurs — preuve que ses travaux sont repris par la communauté médicale.

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Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

Top publications · les plus citées

Causal Assessment of Serum Urate Levels in Cardiometabolic Diseases Through a Mendelian Randomization Study

Journal of the American College of Cardiology · 2016

📚 144 citations🎯 RCR 5.60Top 7% NIH

Intentional self-poisoning with the chlorophenoxy herbicide 4-chloro-2-methylphenoxyacetic acid (MCPA)

Annals of emergency medicine · 2005

📚 37 citations🎯 RCR 1.48🔓 Open Access

Prediction of paraquat exposure and toxicity in clinically ill poisoned patients: a model based approach

British journal of clinical pharmacology · 2014

📚 33 citations🎯 RCR 1.53🔓 Open Access📄 PDF gratuit ↗

Lire l'abstract Crossref ↓

AimsParaquat poisoning is a medical problem in many parts of Asia and the Pacific. The mortality rate is extremely high as there is no effective treatment. We analyzed data collected during an ongoing cohort study on self‐poisoning and from a randomized controlled trial assessing the efficacy of immunosuppressive therapy in hospitalized paraquat‐intoxicated patients. The aim of this analysis was to characterize the toxicokinetics and toxicodynamics of paraquat in this population.MethodsA non‐linear mixed effects approach was used to perform a toxicokinetic/toxicodynamic population analysis in a cohort of 78 patients.ResultsThe paraquat plasma concentrations were best fitted by a two compartment toxicokinetic structural model with first order absorption and first order elimination. Changes in renal function were used for the assessment of paraquat toxicodynamics. The estimates of toxicokinetic parameters for the apparent clearance, the apparent volume of distribution and elimination half‐life were 1.17 l h−1, 2.4 l kg−1 and 87 h, respectively. Renal function, namely creatinine clearance, was the most significant covariate to explain between patient variability in paraquat clearance.This model suggested that a reduction in paraquat clearance occurred within 24 to 48 h after poison ingestion, and afterwards the clearance was constant over time. The model estimated that a paraquat concentration of 429 μg l−1 caused 50% of maximum renal toxicity. The immunosuppressive therapy tested during this study was associated with only 8% improvement of renal function.ConclusionThe developed models may be useful as prognostic tools to predict patient outcome based on patient characteristics on admission and to assess drug effectiveness during antidote drug development.

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M Mohammed FAHIM

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Publications scientifiques (13) — classées par pathologie

Transversal7

Case report / série1

Épidémiologie & registres1

Essai clinique1

Lupus1

Revue générale1

Vraie vie / RWE1

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