📇 Rhumatologue ·

M JEAN-LUC ELGHOZI

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Forme la prochaine génération de rhumatologues (6 thèses dirigées)

Rhumatologue

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📊 Reconnaissance scientifique : 34/100📝 161 articles publiés🇫🇷 Publications académiques françaises (6)🎓 6 thèses dirigées

✨ Génération du profil synthétique IA en cours…

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🎓 6 thèses dirigées

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Top publications · les plus citées

Short-term blood pressure and heart rate variability in congenital central hypoventilation syndrome (Ondine's curse)

Clinical science (London, England : 1979) · 2005

📚 56 citations🎯 RCR 1.85

Lire l'abstract Crossref ↓

The effect of CCHS (congenital central hypoventilation syndrome, or Ondine's curse) on short-term BP (blood pressure) and HR (heart rate) variability was evaluated in 16-year-old subjects presenting a form of CCHS requiring night ventilatory assistance. The 12 patients were compared with 12 age- and gender-matched healthy volunteers. Recordings were obtained during daytime while the subjects were breathing spontaneously. Continuous BP was measured with a Finapres® device in the supine, head-up tilt and standing positions. The manoeuvre of actively standing was also analysed. HR levels were elevated in CCHS subjects at supine rest (+23%) with a reduced HR overall variability (−88%). The low- and high-frequency components of HR variability were affected. BP levels were preserved at rest, but the manoeuvres demonstrated a limited capacity to elevate BP. There was no overshoot in BP during the manoeuvre of actively standing, and steady standing BP levels in patients were not higher than supine BP levels as usually observed in healthy controls. The spontaneous baroreflex sensitivity estimated using the sequence technique or the cross-spectral analysis fell in the patients to approx. one-third of the sensitivity estimated in the healthy controls whatever the position. This cardiovascular profile suggests a predominant vagal dysfunction with signs of vagal withdrawal and baroreflex failure, and relative preservation of the cardiac and vascular sympathetic function. It is likely that the impaired ontogeny of the visceral reflexes, considered now to cause CCHS syndrome, includes the baroreceptive pathway and mainly its vagal component.

Tuning of the sequence technique

IEEE engineering in medicine and biology magazine : the quarterly magazine of the Engineering in Medicine & Biology Society · 2009

📚 25 citations🔓 Open Access

Visualizing oxidative stress-induced depression of cardiac vagal baroreflex by MRI/DTI in a mouse neurogenic hypertension model

NeuroImage · 2013

📚 24 citations

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M JEAN-LUC ELGHOZI

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Publications scientifiques (4) — classées par pathologie

Transversal3

Santé mentale / fatigue1

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