M DOMINIQUE DUBOIS

Rhumatologue

RPPS 10000746890

📊 Reconnaissance scientifique : 26/100📝 99 articles publiés🇫🇷 Publications académiques françaises (8)

✨ Génération du profil synthétique IA en cours…

Activité de recherche & publications

Indicateurs publics agrégés sur 250 M+ d'œuvres scientifiques (OpenAlex, PubMed). Traduits ici en langage patient.

Influence scientifique

26 articles ont été cités au moins 26fois par d'autres chercheurs — preuve que ses travaux sont repris par la communauté médicale.

Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

Articles de presse (6)

Source : Google News (recherche par nom complet — homonymes possibles, vérifier le contenu).

Dans la région de Montaigu aussi, la pénurie de médecins gagne du terrain - Ouest-France

📰 Ouest-France · 07/06/2023

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À Neulliac, les élus tirent le bilan de 3 ans d’efforts pour les jeunes - Ouest-France

📰 Ouest-France · 19/04/2023

<a href="https://news.google.com/rss/articles/CBMi7wFBVV95cUxPS1hZUnY1TUxIeVRFMl9DLVNZQWt0ZkdKQld5QnY5X1JKaWhvQ1ZVVjhKVFdGQjZQQjhpbG5iRkluZm1CeVJYVG10VXNubTlfQXB4OUwxUVIxdlQyeWlUSEtiV3pHbXluNF9RUFdNclhmR25DZG1rZHVObGNmLXBNcnFablNFeFd1cjJjVThwSnZwZmVjUmZocUxhdkNJaGdOWURwWGVwWUxJdnY3d2RXU1hwMm9mMHB0Yk

Municipales : la liste de Bernard Delhaye - Actu.fr

📰 Actu.fr · 28/02/2014

<a href="https://news.google.com/rss/articles/CBMilgFBVV95cUxOdTVHQnNweUVDY1VlMU5VXzNRR0ZHRzNSczVLTksyTXB6Snl5V2Y0Y0RkR1pwMnRrUmVLQ01sRDZvaFlRdW5FazQ3MEFZRGJ2dUE3RkJFbnM3dzJMdmpCLTVvc3Q5ckpTdnRVT2hrWEt5WUVHLUhsWkhFNHJrM2trVFpYSks3dklmYkw2dHNQUWJYYTZnVlE?oc=5" target="_blank">Municipales : la liste d

Par contre, « 50 jours en mer, c’est long » : cap passé pour les Morbihannais de l’Ocean Globe Race - Ouest-France

📰 Ouest-France · 30/10/2023

<a href="https://news.google.com/rss/articles/CBMiyAFBVV95cUxONWVWQ09EOXU5MHBTZEZiM0YydTBxbzh6ZUd4WDh1emxKcWNTUUFqNkVsRlktalZlYnBRQ2U1T213bWhoZ1hILWZsaG1FTUJmVnh1NEM4WXNLVHNkR3dkbzY0ZmFBeTVCc2ViYzJEcjhTenlNOVF6aHpORTVzc1RPdVAtRnRUNkpnc0w4N1dQLUk1RWhMS3ZFQ2pqZnB2bmhReklKc0RBWnhpMXBwWG9zeGtGZnNKRVZOQz

Cléguérec. Départs à la retraite au centre communal d’action sociale - Ouest-France

📰 Ouest-France · 02/02/2024

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Municipales à Neulliac. Le maire Jean-Pierre Le Ponner a présenté ses colistiers et colistières - Ouest-France

📰 Ouest-France · 17/02/2020

<a href="https://news.google.com/rss/articles/CBMi4gFBVV95cUxPNjdHYmltd25zX044YUZlX1lGa2w2TktBcjNURDAwN3hockNjYzVHYU1uWWFCNEZtQzRicUx6VnphUUhRcTFJM0lORHJHdFhGSTlOV3IydDVvWFBGMkoxYkRwTHRDb0FqMzNDSy10RGlTQ1ZGZENMZXNRZ2VSektZSVNRVlVKenh6OFZXSWJsNzlmWWwxLTJGY2pEMnVtSDV2eUlkTlVOcktCekx0Z0NWTXV4cVNLSmhVem

Top publications · les plus citées

Validation of the PAC-SYM questionnaire for opioid-induced constipation in patients with chronic low back pain

European journal of pain (London, England) · 2006

📚 89 citations🎯 RCR 3.37Top 14% NIH🩺 Clinique

Lire l'abstract Crossref ↓

AbstractBackground The Patient Assessment of Constipation Symptoms (PAC‐SYM) questionnaire is a 12‐item self‐report instrument divided into abdominal, rectal and stool domains.Aims This study aimed to (1) evaluate the psychometric properties of PAC‐SYM in assessing the symptoms and severity of opioid‐induced constipation; (2) test for differences in opioid‐induced constipation between Durogesic® fentanyl transdermal reservoir (TDF) and oral sustained‐release morphine (SRM) in patients with chronic low back pain (CLBP).Methods In a 13‐month, open‐label, parallel‐group study, 680 patients were randomised to receive either TDF (n = 338) or SRM (n = 342) for CLBP. Assessments were recorded at Visit 1 (baseline), Visit 5 (Day 29) and Visit 17 (Month 13). Concurrent validity, clinical validity and responsiveness of PAC‐SYM were determined based on patients' confirmation of constipation (CC) scores. Differences in PAC‐SYM scores between treatment groups were also evaluated.Results The study included 677 patients, of whom 638 were opioid‐naïve. Mean PAC‐SYM scores for constipated patients were substantially higher than for non‐constipated patients, demonstrating good clinical validity for PAC‐SYM. The PAC‐SYM could detect changes in bowel function over the treatment period, indicating responsiveness. Homogeneity of each symptom domain exceeded Cronbach's α coefficient of 0.70, suggesting good internal consistency and reliability. Changes in mean PAC‐SYM scores from baseline to Visit 5 and Visit 17 were significantly lower for the TDF group than for the SRM group, indicating that the TDF group experienced less severe constipation.Conclusion PAC‐SYM is a reliable, valid and responsive measure of the presence and severity of opioid‐induced constipation symptoms.

Descriptive and prognostic value of patient-reported outcomes: the bortezomib experience in relapsed and refractory multiple myeloma

Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2006

📚 78 citations🎯 RCR 1.99🩺 Clinique

Lire l'abstract Crossref ↓

Purpose Bortezomib, a boronic acid dipeptide, has been recently introduced as a new approach to treating multiple myeloma (MM). The goal of this work was to evaluate the added value of patient-reported outcomes (PRO) in the interpretation of bortezomib clinical trial outcomes. Patients and Methods Two hundred two patients with relapsed, refractory MM were treated with bortezomib as part of the SUMMIT (Study of Uncontrolled Multiple Myeloma Managed with Proteasome Inhibition Therapy) study. Patients were administered the following four PRO measures at several time points: the European Organisation for Research and Treatment of Cancer (EORTC) core Quality of Life Questionnaire (QLQ-C30) and the myeloma-specific module (QLQ-MY24), the Functional Assessment of Chronic Illness Therapy (FACIT) Fatigue scale, and the Functional Assessment of Cancer Therapy (FACT)/Gynecologic Oncology Group (GOG) Neurotoxicity (Ntx) scale. Minimal important difference (MID) thresholds were used to define patients as improved, stable, or worsened. A survival analysis was conducted to assess the predictive power of PRO data. Results For the total population, there was a positive change between baseline and best end point. Consistent with the clinical responses, change in PRO scores showed statistically significant differences between response groups with PRO improvement in patients with complete response (CR) or partial response (PR), mostly stable scores in patients with minor response or no change, and deterioration in most scores for patients with progressive disease. Change in scores for neuropathy-related symptoms was reasonably stable. In contrast, fatigue scores significantly improved for patients with CR or PR. When various MID thresholds were applied, the proportion of improved patients exceeded 35% for several domains within all change group definitions. Moreover, survival analysis results demonstrated the additional prognostic information PRO data can provide to supplement clinical data. Conclusion This study demonstrated the complementary value for PRO assessments in further interpreting clinical response, the impact of adverse effects, and patient prognosis in clinical trials.

Use of patient-reported sleep measures in clinical trials of pain treatment: a literature review and synthesis of current sleep measures and a conceptual model of sleep disturbance in pain

Clinical therapeutics · 2007

📚 74 citations🎯 RCR 2.84Top 17% NIH

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Articles de presse (6)

Top publications · les plus citées

Publications scientifiques (37) — classées par pathologie

Transversal8

Qualité de vie / PROMs6

AINS3

Anti-TNF3

Pédiatrie3

Santé mentale / fatigue3

Corticothérapie2

Essai clinique2

JAK inhibiteurs2

Revue générale2

Biothérapies non-anti-TNF1

csDMARDs1

Économie santé1

Lombalgie1

Lupus1

Vraie vie / RWE1

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