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2 raisons identifiées
Auteur de référence en rhumatologie
26 articles scientifiques publiés — un praticien à la pointe de la recherche
Délais de RDV courts dans la région
65.4 rhumatos / 100 000 hab. — département bien doté
✨ Génération du profil synthétique IA en cours…
CABINET DU DR PASCALE DEDECIUSZ
63 AVENUE DE LA RESISTANCE, 77500 CHELLES
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
JAMA · 2026
Importance Sepsis is heterogeneous, and the optimal strategy for tailoring immunotherapy is uncertain. Objective To investigate whether precision immunotherapy guided by the presence of macrophage activation–like syndrome or sepsis-induced immunoparalysis improves organ dysfunction by day 9. Design, Setting, and Participants A randomized, double-blind, double-dummy, placebo-controlled clinical trial conducted in 6 countries. Patients with sepsis, defined by Sepsis-3, were included if they had community-acquired or hospital-acquired pneumonia or ventilator-associated pneumonia or bacteremia and sepsis and had displayed either macrophage activation–like syndrome (blood ferritin >4420 ng/mL) or sepsis-induced immunoparalysis (blood ferritin ≤4420 ng/mL and <5000 human leukocyte antigen DR receptors on CD45/CD14 monocytes). The first patient was enrolled August 5, 2021, and the last follow-up, April 29, 2024. Interventions Eligible patients were randomized to receive standard care and precision immunotherapy or standard care and placebo. Those in the precision immunotherapy group with macrophage activation–like syndrome received anakinra intravenously (IV) and placebo subcutaneously, and those with sepsis-induced immunoparalysis received subcutaneous recombinant human interferon gamma and IV placebo. Those in the placebo group received both IV and subcutaneous placebo. Treatment was administered for up to 15 days. Main Outcomes and Measures The primary end point was a decrease of at least 1.4 points in the mean Sequential Organ Failure Assessment (SOFA) score from baseline by day 9. The SOFA score evaluates 6 organ systems, ranging from 0, no dysfunction, to 4, failure, and the total score ranges from 0, normal, to 24, most severe form of multiorgan failure. Key secondary outcomes included 28-day mortality. Results Of 672 patients assessed for eligibility, 281 were randomized and 276 were included in the primary analysis population (mean [SD] age, 70 [13] years; 93 females [33.7%]; median baseline SOFA score, 9 [IQR, 7-11]). The SOFA decrease end point was attained by 46 of 131 patients (35.1%) in the precision immunotherapy group and by 26 of 145 patients (17.9%) in the placebo group (difference, 17.2% [95% CI, 6.8% to 27.2%]; P = .002). Mortality at 28 days was not statistically significantly different between groups. A total of 1069 serious treatment-emergent adverse events (88.8%) were reported; increased incidence of anemia was noted in the anakinra group; and hemorrhage in the recombinant human interferon gamma group. Conclusions and Relevance Among patients with sepsis, precision immunotherapy targeting macrophage activation–like syndrome and sepsis-induced immunoparalysis improved organ dysfunction by day 9 compared with placebo. Trial Registration ClinicalTrials.gov Identifier: NCT04990232
Critical care medicine · 2026
Nursing administration quarterly · 2026
In hospitals, the cost to replace 1 registered nurse (RN) can be quantified by considering costs in recruitment, hiring, and onboarding processes. Though the mean replacement cost of 1 RN will vary depending on geographic location and professional specialization, some have estimated this cost at $56 000. In addition to these direct costs, high turnover also contributes to broader organizational challenges, including disrupted communication, teamwork, and patient care. These challenges can contribute to adverse quality outcomes, such as increased inpatient falls. This article examines the organizational cost of RN turnover by analyzing its relationship to inpatient fall rates as an indicator of quality care.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
European heart journal supplements : journal of the European Society of Cardiology · 2026 · Journal Article
Riccio C, Fattirolli F, Ambrosetti M, Geraci G, et al.
Intensive care medicine · 2026 · Published Erratum
Prescott HC, Antonelli M, Alhazzani W, Møller MH, et al.
Nursing outlook · 2026 · Journal Article
Lake ET, Pascale A, Warshawsky NE, Henderson JG, et al.
Journal of ultrasonography · 2026 · Journal Article
Pacella G, Bruno M, Liguori L, Pascale A, et al.
Journal of experimental & clinical cancer research : CR · 2026 · Journal Article
Frascolla C, Mastroianni R, Macedo-Silva C, De Menna M, et al.
Critical care medicine · 2026 · Journal Article
Prescott HC, Antonelli M, Alhazzani W, Møller MH, et al.
Critical care medicine · 2026 · Journal Article
Prescott HC, Antonelli M, Alhazzani W, Møller MH, et al.
Nursing administration quarterly · 2026 · Journal Article
Pascale A, Welch TD, Smith TB, Warshawsky NE
Intensive care medicine · 2026 · Journal Article
Prescott HC, Antonelli M, Alhazzani W, Møller MH, et al.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2026 · Journal Article
de Pascale S, Rosati R, Bagnardi V, Cossu A, et al.
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2026 · Journal Article
Pascale R, Fernández-Hidalgo N, Tazza B, Bartoletti M, et al.
Journal of studies on alcohol and drugs · 2026 · Journal Article
Mikl J, Yu T, Singh S, Zhao X, et al.
Intensive care medicine experimental · 2026 · Journal Article
Eleuteri D, Del Tedesco F, Silvia F, Tucciariello C, et al.
The Journal of arthroplasty · 2026 · Journal Article
Kashir I, Shanthanna H, Khanna V, Mbuagbaw L, et al.
Intensive & critical care nursing · 2026 · Journal Article
Donckels F, Antonelli M, Arvaniti K, Creagh-Brown B, et al.
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2026 · Journal Article
Marrelli D, Carbone L, Piccioni SA, Torroni L, et al.
Clinical cancer research : an official journal of the American Association for Cancer Research · 2026 · Journal Article
Campani C, Shim JH, Bouattour M, Touchefeu Y, et al.
Dentistry journal · 2026 · Journal Article
Abbinante A, Barile G, Antonacci A, Basso M, et al.
JAMA · 2026 · Clinical Trial, Phase II
Giamarellos-Bourboulis EJ, Kotsaki A, Kotsamidi I, Efthymiou A, et al.
The Journal of nursing administration · 2026 · Journal Article
Warshawsky NE, Pascale A, Duemig MJ
The Annals of pharmacotherapy · 2026 · Journal Article
Pascale S, Reinert JP
Journal of personalized medicine · 2026 · Journal Article
Camardese G, Pascale MM, D'Onofrio AM, Calia R, et al.
MicrobiologyOpen · 2026 · Systematic Review
Hommel B, Hurtado O, Noble B, Jones J, et al.
Chinese medical journal · 2026 · Journal Article
Leng X, Liu Y, Tang L, Sun L, et al.
Antibiotics (Basel, Switzerland) · 2026 · Journal Article
Cojutti PG, Pascale R, Grechi A, Ambretti S, et al.
Food research international (Ottawa, Ont.) · 2026 · Journal Article
Calvo-Lerma J, Bäuerl C, Arena S, Ciaravolo V, et al.
MicrobiologyOpen · 2026 · Systematic Review
Hommel B, Hurtado O, Noble B, Jones J, et al.
Clinical cancer research : an official journal of the American Association for Cancer Research · 2026 · Journal Article
Campani C, Shim JH, Bouattour M, Touchefeu Y, et al.