📇 Rhumatologue · PARIS · (75) · Salarié

M RAPHAEL-DANY COHEN

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3 raisons identifiées

Auteur de référence en rhumatologie
50 articles scientifiques publiés — un praticien à la pointe de la recherche
Expérience confirmée
40 ans d'exercice en rhumatologie — recul clinique solide
Délais de RDV courts dans la région
336.2 rhumatos / 100 000 hab. — département bien doté

Rhumatologue

📍 PARIS (75)SalariéRPPS 10000383157

Expérience confirmée

40ans d'exercice (thèse 1986)

✨ Génération du profil synthétique IA en cours…

Thèses universitaires

Les hyperplaquettoses de l'enfant : a propos d'une observation de thrombocytemie essentielle
1986
Médecine🎓 Université Louis Pasteur (Strasbourg) (1971-2008)
Patrick Lutz

Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

Top publications · les plus citées

Expanded double negative T cells in patients with systemic lupus erythematosus produce IL-17 and infiltrate the kidneys

Journal of immunology (Baltimore, Md. : 1950) · 2008

📚 628 citations🎯 RCR 13.34Top 2% NIH🔓 Open Access📄 PDF gratuit ↗

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Abstract Double negative (DN) T cells are expanded in patients with systemic lupus erythematosus (SLE) and stimulate autoantibody production as efficiently as CD4+ T cells. In this study, we demonstrate that DN T cells from patients with SLE produce significant amounts of IL-17 and IFN-γ, and expand when stimulated in vitro with an anti-CD3 Ab in the presence of accessory cells. Furthermore, IL-17+ and DN T cells are found in kidney biopsies of patients with lupus nephritis. Our findings establish that DN T cells produce the inflammatory cytokines IL-17 and IFN-γ, and suggest that they contribute to the pathogenesis of kidney damage in patients with SLE.

Hydroxychloroquine to Prevent Recurrent Congenital Heart Block in Fetuses of Anti-SSA/Ro-Positive Mothers

Journal of the American College of Cardiology · 2020

📚 142 citations🎯 RCR 10.53Top 2% NIH🩺 Clinique🔓 Open Access

Medium-term results of permanent sacral nerve stimulation for faecal incontinence

The British journal of surgery · 2002

📚 133 citations🎯 RCR 5.37Top 7% NIH🔓 Open Access📄 PDF gratuit ↗

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Abstract Background Anal sphincter surgery for faecal incontinence is associated with significant morbidity and a variable outcome. Sacral nerve stimulation may provide a good functional outcome with minimal morbidity. This paper reports the experience in a single centre over 5 years. Methods Fifteen consecutive patients (14 women), median age 60 (range 37–71) years, underwent temporary, and subsequent permanent, stimulation. All had incontinence to solid or liquid stool; the aetiology was obstetric injury (seven patients), scleroderma (four), idiopathic (two), fistula surgery (one) and repaired rectal prolapse (one). Median duration of symptoms was 6 (range 2–15) years. Clinical evaluation, endoanal ultrasonography, bowel diary, quality of life questionnaire (Short Form (SF) 36) and anorectal physiological testing were performed before and after stimulation. Results Continence had improved in all patients at median follow-up of 24 (range 3–60) months. Eleven patients were fully continent. Episodes of faecal incontinence decreased from median (range) 11 (2–30) per week before stimulation to 0 (0–4) per week after permanent stimulation (P &lt; 0·001). Urgency improved in all patients (median (range) ability to defer less than 1 (0–1) versus 8 (1–15) min; P = 0·01). ‘Social function’ and ‘role-physical’ subscales of the SF36 improved significantly. Mean resting pressure (35 versus 49 cmH2O with temporary stimulation; P &lt; 0·05) and squeeze pressure increment (43 versus 69 cmH2O with permanent stimulation; P &lt; 0·01) increased. Rectal sensitivity to initial distension changed (mean 47 versus 34 ml air; P &lt; 0·05). There were no major complications. Conclusion Sacral nerve stimulation is a safe and effective treatment for faecal incontinence when conventional treatment has failed. There is minimal morbidity. The benefit is maintained in the medium term.

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M RAPHAEL-DANY COHEN

Pourquoi vous devez consulter ce praticien

Thèses universitaires

Lieu de consultation

Tarifs & secteur de conventionnement

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Top publications · les plus citées

Publications scientifiques (50) — classées par pathologie

Transversal27

Anti-TNF7

Pédiatrie5

Lupus3

csDMARDs2

Anti-IL-171

Biothérapies non-anti-TNF1

CPPD1

Goutte1

Qualité de vie / PROMs1

Revue générale1

Vascularites1

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