📇 Rhumatologue · PARIS 6E ARRONDISSEMENT · (75) · Mixte

M GEORGES CAPUTO

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Auteur de référence en rhumatologie
32 articles scientifiques publiés — un praticien à la pointe de la recherche
En plein centre-ville
PARIS 6E ARRONDISSEMENT (75006) — accessible depuis tout le bassin urbain
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5 lieux d'exercice — choisissez celui qui vous arrange
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336.2 rhumatos / 100 000 hab. — département bien doté

Rhumatologue

📍 PARIS 6E ARRONDISSEMENT (75)MixteRPPS 10000543370

🇫🇷 Publications académiques françaises (6)

✨ Génération du profil synthétique IA en cours…

Publications académiques en France

Articles déposés en accès libre sur l'archive ouverte des universités françaises (HAL) — gage d'activité de recherche en France.

First implication of <i>MIP</i> in bilateral microphthalmia with persistent fetal vasculature
2023
Article

Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

Top publications · les plus citées

Irisin Serum Levels and Skeletal Muscle Assessment in a Cohort of Charcot-Marie-Tooth Patients

Frontiers in endocrinology · 2022

📚 19 citations🎯 RCR 2.24Top 23% NIH🔓 Open Access📄 PDF gratuit ↗

Lire l'abstract Crossref ↓

BackgroundCharcot-Marie-Tooth (CMT) indicates a group of inherited polyneuropathies whose clinical phenotypes primarily include progressive distal weakness and muscle atrophy. Compelling evidence showed that the exercise-mimetic myokine irisin protects against muscle wasting in an autocrine manner, thus possibly preventing the onset of musculoskeletal atrophy. Therefore, we sought to determine if irisin serum levels correlate with biochemical and muscle parameters in a cohort of CMT patients.MethodsThis cohort study included individuals (N=20) diagnosed with CMT disease. Irisin and biochemical markers were quantified in sera. Skeletal muscle mass (SMM) was evaluated by bioelectric impedance analysis, muscle strength by handgrip, and muscle quality was derived from muscle strength and muscle mass ratio.ResultsCMT patients (m/f, 12/8) had lower irisin levels than age and sex matched healthy subjects (N=20) (6.51 ± 2.26 vs 9.34 ± 3.23 μg/ml; p=0.003). SMM in CMT patients was always lower compared to SMM reference values reported in healthy Caucasian population matched for age and sex. Almost the totality of CMT patients (19/20) showed low muscle quality and therefore patients were evaluated on the basis of muscle strength. Irisin was lower in presence of pathological compared to normal muscle strength (5.56 ± 1.26 vs 7.67 ± 2.72 μg/ml; p=0.03), and directly correlated with the marker of bone formation P1PN (r= 0.669; 95%CI 0.295 to 0.865; p=0.002), but inversely correlated with Vitamin D (r=-0.526; 95%CI -0,791 to -0,095; p=0.017). Surprisingly, in women, irisin levels were higher than in men (7.31 ± 2.53 vs 5.31 ± 1.02 μg/ml, p=0.05), and correlated with both muscle strength (r=0.759; 95%CI 0.329 to 0.929; p=0.004) and muscle quality (r=0.797; 95%CI 0.337 to 0.950; p=0.006).ConclusionOur data demonstrate lower irisin levels in CMT patients compared to healthy subjects. Moreover, among patients, we observed, significantly higher irisin levels in women than in men, despite the higher SMM in the latter. Future studies are necessary to establish whether, in this clinical contest, irisin could represent a marker of the loss of muscle mass and strength and/or bone loss.

Natural History and Surgical Outcomes of Lamellar Macular Holes

Ophthalmology. Retina · 2024

📚 13 citations🎯 RCR 7.63Top 4% NIH

Risk Factors for Retinal Detachment in Marfan Syndrome After Pediatric Lens Removal

American journal of ophthalmology · 2024

📚 7 citations🎯 RCR 3.46Top 13% NIH

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M GEORGES CAPUTO

Pourquoi vous devez consulter ce praticien

Publications académiques en France

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Top publications · les plus citées

Publications scientifiques (32) — classées par pathologie

Pédiatrie13

Transversal12

Épidémiologie & registres9

Pharmacovigilance1

Revue générale1

Vraie vie / RWE1

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