📇 Rhumatologue · NEUILLY SUR SEINE · (92) · Libéral

MME SAIDA BERBACHE-SIDHOUM

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33 articles scientifiques publiés — un praticien à la pointe de la recherche
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Rhumatologue

📍 NEUILLY SUR SEINE (92)LibéralRPPS 10001399491

✨ Génération du profil synthétique IA en cours…

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HARTMANN GROUPE HOSPITALIER PRIVE AMBROISE PARE 48 TER BOULEVARD VICTOR HUGO, 92200 NEUILLY SUR SEINE
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Top publications · les plus citées

Multiomics analysis reveals the genetic and epigenetic features of high-risk NK cell-type chronic active EBV infection

Blood · 2025

📚 3 citations🔓 Open Access

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Abstract Chronic active Epstein-Barr virus (EBV) infection (CAEBV) is an orphan disease characterized by the proliferation and infiltration of EBV-infected T/natural killer (NK) cells into multiple organs. Although CAEBV is a heterogeneous disease with diverse clinical courses, its pathogenesis remains poorly understood. In this study, we explored the molecular mechanisms underlying CAEBV by performing a comprehensive multiomics analysis, including genome, transcriptome, epigenome, and single-cell transcriptome and surface proteome analyses, of 65 patients with CAEBV. Methylation analysis identified 2 distinct subtypes of NK cell–type CAEBV based on the CpG island methylator phenotype (CIMP). In CIMP-positive CAEBV, regions associated with enhancer of zeste homolog 2 binding sites and histone H3 lysine 27 trimethylation exhibited increased DNA hypermethylation, resulting in downregulation of tumor suppressor and antiherpesvirus genes. CIMP-positive CAEBV had a particularly poor prognosis and displayed a “neoplastic” phenotype with a DNA methylation pattern similar to that of extranodal NK/T-cell lymphoma, a higher tumor mutation burden, and frequent copy number alterations. In addition, both in vitro and in vivo functional assays demonstrated that 5-azacytidine, a hypomethylating agent, was a potentially effective agent for high-risk CIMP-positive CAEBV. Finally, we established a method to effectively detect EBV-infected cells in single-cell analysis, suggesting that EBV-infected NK cells have tissue-resident properties and that innate and adaptive immunity to EBV is compromised in patients with CAEBV. The present findings provide insight into the complex molecular features of CAEBV and suggest potential molecular therapies.

Illuminating radiogenomic signatures in pediatric-type diffuse gliomas: insights into molecular, clinical, and imaging correlations. Part I: high-grade group

La Radiologia medica · 2025

📚 3 citations🔓 Open Access📄 PDF gratuit ↗

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Abstract Recent advances in molecular genetics have revolutionized the classification of pediatric-type high-grade gliomas in the 2021 World Health Organization central nervous system tumor classification. This narrative review synthesizes current evidence on the following four tumor types: diffuse midline glioma, H3 K27-altered; diffuse hemispheric glioma, H3 G34-mutant; diffuse pediatric-type high-grade glioma, H3-wildtype and IDH-wildtype; and infant-type hemispheric glioma. We conducted a comprehensive literature search for articles published through January 2025. For each tumor type, we analyze characteristic clinical presentations, molecular alterations, conventional and advanced magnetic resonance imaging features, radiological-molecular correlations, and current therapeutic approaches. Emerging radiogenomic approaches utilizing artificial intelligence, including radiomics and deep learning, show promise in identifying imaging biomarkers that correlate with molecular features. This review highlights the importance of integrating radiological and molecular data for accurate diagnosis and treatment planning, while acknowledging limitations in current methodologies and the need for prospective validation in larger cohorts. Understanding these correlations is crucial for advancing personalized treatment strategies for these challenging tumors.

Evaluation of lumbar intervertebral disc degeneration using (23)Na-MRI in clinical settings

Skeletal radiology · 2025

📚 2 citations

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MME SAIDA BERBACHE-SIDHOUM

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Top publications · les plus citées

Publications scientifiques (33) — classées par pathologie

Transversal12

Pédiatrie6

Case report / série4

Revue générale4

Génétique2

IRM ostéo-articulaire2

Économie santé1

Essai clinique1

Lupus1

Santé mentale / fatigue1

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