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Praticien-chercheur
18 articles scientifiques publiés — formation continue solide
✨ Génération du profil synthétique IA en cours…
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Lupus · 2008
Mycophenolate mofetil (MMF) with prednisolone has been associated with high remission rates when used as induction treatment for lupus nephritis. This prospective, multicentre, cohort study investigates the efficacy and safety of this regimen over 24 weeks in 213 Chinese patients with active lupus nephritis (Classes III, IV, V or combination). Baseline activity index (AI) was 6.91 ± 3.33 and chronicity index (CI) was 1.9 ± 1.2. The remission rate was 82.6% at 24 weeks (complete remission, 34.3%; partial remission, 48.4%). There were significant ( P < 0.01) improvements in kidney function shown by reductions in proteinuria, serum albumin, serum creatinine and creatinine clearance, as well as in systemic lupus erythematosus disease activity index (SLEDAI) scores. Independent risk factors influencing remission were pathological classification (including Class V and III or Class V and IV nephritis) and elevated serum creatinine at baseline (OR 2.967, 95% CI: 1.479–6.332, P = 0.001 and OR 1.007, 95% CI: 1.002–1.011, P = 0.001, respectively). Patients with concomitant membranous features on biopsy had a lower remission rate than those with Class III and IV nephritis (66.7% vs 87.3%, P = 0.002). Renal biopsy was repeated in 25 patients following treatment. There was a transition to less severe pathological morphologies in majority of subjects. Infections were monitored throughout treatment: eight patients (3.8%) experienced bacterial infections, whereas herpes zoster occurred in seven patients. Nine patients (4.2%) suffered from gastrointestinal upset, which resolved without discontinuation of MMF. One patient became leucopenic, whereas another died from active disease unrelated to kidney symptoms. MMF combined with prednisolone is an effective and well-tolerated induction treatment for patients with active lupus nephritis and for controlling SLE systemic activity.
Journal of general internal medicine · 2016
Clinical nephrology · 2009
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
The Journal of the Association of Physicians of India · 2022 · Journal Article
Nair A, Pruthi P, L S, Marwaha V, et al.
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases · 2021 · Journal Article
Alexander LAM, Ln D, Eg Z, Is D, et al.
PloS one · 2020 · Journal Article
Desai G, T S J, G SK, L M, et al.
Journal of palliative medicine · 2019 · Journal Article
Lucette A
Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2019 · Journal Article
Ting A, Lucette A, Carver CS, Cannady RS, et al.
Journal of religion and health · 2018 · Journal Article
Ironson G, Lucette A, Hylton E, Pargament KI, et al.
Psychosomatics · 2016 · Journal Article
Lucette A, Ironson G, Pargament KI, Krause N
Journal of general internal medicine · 2016 · Journal Article
Ironson G, Kremer H, Lucette A
Psycho-oncology · 2014 · Journal Article
Adams RN, Mosher CE, Cannady RS, Lucette A, et al.
European journal of cancer care · 2014 · Journal Article
Lucette A, Brédart A, Vivat B, Young T
Experimental and therapeutic medicine · 2013 · Journal Article
Wong JY, Chen YS, Chakravarthi S, Judson JP, et al.
Journal of palliative medicine · 2013 · Journal Article
Kim Y, Carver CS, Schulz R, Lucette A, et al.
Clinical nephrology · 2009 · Journal Article
Nebuloni M, Barbiano di Belgiojoso G, Genderini A, Tosoni A, et al.
Cureus · 2025 · Case Reports
Ghosh S, Vittobarao PG, S S, L A, et al.
Lupus · 2008 · Clinical Trial
F L, Y T, X P, L W, et al.
Frontiers in artificial intelligence · 2025 · Journal Article
Goel C, X A, L JA
Cancer journal (Sudbury, Mass.) · 2013 · Journal Article
Kim Y, Lucette A, Loscalzo M
Zhongguo gu shang = China journal of orthopaedics and traumatology · 2023 · Meta-Analysis
Zhou GB, Lyu Y, L J, Lin ZH, et al.